Vesicle trafficking from a lipid perspective

Vesicle trafficking from a lipid perspective

The protein cargo transported by specific types of vesicles largely defines the different secretory trafficking pathways operating within cells. However, mole per mole the most abundant cargo contained within transport vesicles is not protein, but lipid. Taking a "lipid-centric" point-of-view, we examine the importance of lipid signaling, membrane lipid organization and lipid metabolism for ves...

LRRK2 and vesicle trafficking.

Mutations in LRRK2 (leucine-rich repeat kinase 2) (also known as PARK8 or dardarin) are responsible for the autosomal-dominant form of PD (Parkinson's disease). LRRK2 mutations were found in approximately 3-5% of familial and 1-3% of sporadic PD cases with the highest prevalence (up to 40%) in North Africans and Ashkenazi Jews. To date, mutations in LRRK2 are a major genetic risk factor for fam...

Exercise-Regulated Vesicle Trafficking

TRP_2, a lipid/trafficking domain that mediates diacylglycerol-induced vesicle fusion.

We recently modeled transient receptor potential (TRP) channels using the Gestalt Domain Detection Algorithm-Basic Local Alignment Tool (GDDA-BLAST), which derives structural, functional, and evolutionary information from primary amino acid sequences using phylogenetic profiles ( Ko, K. D., Hong, Y., Chang, G. S., Bhardwaj, G., van Rossum, D. B., and Patterson, R. L. (2008) Physics Arch. Quant....

Vesicle Trafficking: A Rab Family Profile

A new tool-kit has been developed for profiling expression and function of Rab GTPases on a genome-wide scale. Use of this tool-kit has revealed unexpectedly that at least half of Drosophila Rabs have neuronal-specific expression patterns and localize to synapses.